Natureza Presents New Antibiotic Agents at Conference on Drug Development
Preclinical evaluation of a novel membrane-intercalating agent shows antibacterial activity with no generation of bacterial resistance. Membrane fluidity is key to the function of prokaryotic and eukaryotic cells. Natureza Products, Inc has developed chitosan-coated esters of dodecanoic acid as membrane intercalating agents with anti-inflammatory and antibacterial properties. These can be targeted to Gram-positive or negative bacteria by alteration of charge and decoration on the chitosan coat, and bacteria show no innate or evolved resistance to these agents on exposure. [read more]