Natureza Products, Inc. is at the ESCMID/ASM Conference on Drug Development in Dublin presenting data on two of our novel anti-infectives.
The 2022 ASM/ESCMID Joint Conference on Drug Development to Meet the Challenge of Antimicrobial Resistance
October 4-7, 2022 in Dublin, Ireland
Natureza Products, Inc. is at the ESCMID/ASM Conference on Drug Development in Dublin presenting data on two of our novel anti-infectives.
The 2022 ASM/ESCMID Joint Conference on Drug Development to Meet the Challenge of Antimicrobial Resistance
October 4-7, 2022 in Dublin, Ireland
Co-sponsored by ASM and the European Society for Clinical Microbiology and Infectious Diseases (ESCMID), this multidisciplinary meeting will highlight the challenges, opportunities and current requirements for antimicrobial drug development to address antimicrobial resistance. Location: Crowne Plaza Dublin – Blanchardstown, Blanchardstown Town Centre , Dublin 15. | Conference Website
Preclinical evaluation of a novel membrane-intercalating agent shows antibacterial activity with no generation of bacterial resistance.
Preclinical evaluation of a novel membrane-intercalating agent shows antibacterial activity with no generation of bacterial resistance
Membrane fluidity is key to the function of prokaryotic and eukaryotic cells. We have developed chitosan-coated esters of dodecanoic acid as membrane intercalating agents with anti-inflammatory and antibacterial properties. These can be targeted to Gram-positive or negative bacteria by alteration of charge and decoration on the chitosan coat, and bacteria show no innate or evolved resistance to these agents on exposure.
Background
We have observed previously that modification of bacterial membranes by the insertion of lipids with cyclic or branched moieties causes an increase in membrane stability and in bacterial heat tolerance. Where bacteria are unable to alter these lipids their ability to adapt becomes compromised as an increase in stability causes decreased fluidity and ability of the membrane to function.
Natureza Products, Inc. has developed these lipids into orally dosable chitosan-coated particles (PY-1 for Gram positives and PY-3 for Gram negatives) that show activity against many of the WHO priority pathogens and have also shown that these are active in in vivo models.
PY-1
Resistance ~ Two methods:
- Exposure to agents on agar plates with increasing gradient concentrations of agents (MEGA plates) Exposure to long term subinhibitory concentrations of agents
- No resistance developed, no change in MIC over 6 months
PY-3
- Broad spectrum of activity
- Active against ESBL+ bacteria
- Active against carbapenem resistant bacteria
- No resistance seen in any of the target bacteria tested
- No resistance developed on extended testing
PY3 vs Pew Trust Criteria
- Development phase: Preclinical
- Drug class: Carboxylic acid
- Target: Membrane fluidity
- Activity against ESKAPE pathogens: Klebsiella, Enterobacter, Acinetobacter, Pseudomonas; some activity against Staphylococcus
- Activity against WHO/CDC priority pathogens: 13/15
- Potential indications: Enteric salmonellosis; activity predicted against other Gram-negative enteric pathogens
